Nsc 330 Exam 2 Gi Part 1: Antiemetics Qs&as A+ Graded 2024

NSC 330 Exam 2 GI Part 1: Antiemetics Qs&As A+ Graded 2024

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NSC 330 Exam 2 GI Part 1: Antiemetics Qs&As A+ Graded 2024 Vomiting and nausea Stimuli may be relayed from: - 1. Peripheral sites Gastric mucosa Peritoneum Intestines 2. Central sites Cerebral cortex Vestibular apparatus of the ear Chemoreceptor trigger zone or CTZ Promethazine - used for nausea and vomiting Phenothiazines and Promethazine MOA - Decrease response of the CTZ by inhibiting dopamine receptors Promethazine adverse effects - 1. Sedation 2. Anticholinergic effects 3. Hypotension 4. Black Box Warning: Contraindicated in children < 2 due to respiratory depression 5. Not effective for motion sickness Promethazine black box warning *NEED TO KNOW* - Contraindicated in children < 2 y/o due to respiratory depression Promethazine isn't effective for - motion sicknessMeclizine - good for motion sickness (antihistamine) Scopolamine - (anticholinergic) change q 3 days; apply before travel (it's a patch and used for motion sickness) Meclizine and Scopolamine is best for? *NEED TO KNOW* - **Best agents for motion sickness** Meclizine and Scopolamine adverse effects - Drowsiness Anticholinergic (blurred vision, urinary retention, dry mouth, constipation, confusion) (low dose for elderly to avoid AE) What is an example of a Selective Serotonin Antagonists - Ondansetron Ondansetron adverse effects - Drowsiness (minimal) Abdominal pain/bowel