NSC 330 Exam #2 Review Solution A+ aPTT - ANS-normal 20-35 sec Therapeutic range 1.5-2.5 x control values= ineffective tx values= RF bleed Evals Heparin Heparin - ANS-Anti-Coag Contra: no active bleed unless DIC Req 2nd check by RN antidote: Protamine Sulfate INJ only aPTT Coumadin - ANS-Anti-Coag Tx: A. Fib, RF thrombus blocks Vit K and Factor II, VII, IX, X PT/INR given in evening PT/INR - ANS-normal 1-2 seconds therapeutic range 2-3x normal Enoxapren (Lovenox) - ANS-Anti-Coag safer than heparinDeep SQ L/R antero/posterolateral (love handles) things that clotting - ANS-dark green veg, green tea/chamomile, Herbs, St. John's Wort, garlic, licorice, veg oil, tobacco factors that clotting - ANS-ETOH cranberry juice Vit E laxatives-mineral oil NSAIDS/ASA Clopidogrel (Plavix) - ANS-Anti-Platelet given during PCI, reduce MI, CVA, vascular death SE: GI distress --> take c food Dabigatran (Pradaxa) - ANS-Direct Thrombin Inhibitor does not require monitoring or a special diet so it's better for pt but expensive bc it's newer Pentoxifylline (Trental) - ANS-Hemorheologic Drug RBC flexibility to --> viscosity platelet aggregation vasodilation Tx: Intermittent Claudication Warning: don't give to allergy methylxanthines SE: CV, CNS, GI takes several weeks to see effectsNO SMOKING Alteplase/Activase - ANS-Thrombolytic (clot buster) binds to