NSC 330 Diuretic hydrochlorothiazide Questions And Answers How does an hydrothiazide work? - ANS-It acts in the distal tubule. It inhibits the sodium chloride pump which increases the amount of sodium and chloride being excreted in the urine. It also increases the excretion of potassium, bicarbonates and water. What is the prototype drug for a thiazide diuretic? - ANS-hydrochlorothiazide What are the pharmacotherapeutics of hydrochlorothiazide? - ANS-HTN, - used early in renal failure What are the pharmacokinetics of metabolism of hydrochlorothiazide? - ANS-liver What is the pharmacokinetics of excretion of hydrochlorothiazide? - ANS-kidneys What are the contra indications and precautions for hydrochlorothiazide? - ANS-severe renal impairment, anuria, hypersensitivity to thiazides hepatic coma antibacterial sulonamides, allergy to bactrium What are the adverse effects of hydrochlorothiazide? - ANS-hypokalemia, hyponatrium, hypochloremia, hypomagnesemia and HYPERcalcemia When should you give hydrochlorothiazide? (time of day) - ANS-in the morning what should you monitor when using hydrochlorothiazide? - ANS-electrolyte levels, weight, and urine output What electrolyte does hydrochlorothiazide mostly effect? - ANS-sodium and chloride, it pulls other electrolytes out of the blood stream, It increases calcium in the blood streamWhat should you tell your pt. about drinking water when using hydrochlorothiazide? - ANS-drink water or the pill