Nsc 330: Drugs Treating Mild To Moderate Pain, Fever, And Inflammation Qs&as 2023-2024 A+ Graded

NSC 330: Drugs Treating Mild to Moderate Pain, Fever, and InflammationQs&As 2023-2024 A+ Graded

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NSC 330: Drugs Treating Mild to Moderate Pain, Fever, and Inflammation Qs&As 2023-2024 A+ Graded 1 / 4 1. Prostaglandins -Designed to protect the body from injury and pathogens -Helps destroy pathogens and promote healing -Leads to: swelling, pain, fever, erythema -Inflammation can be chronic and cause body damage 2. Prostaglandin action -Protect GI from gastric acid: output of gastric acid, pro- mote secretion of mucus and bicarb, support submucosal blood flow -Stimulate platelet aggregation -Promote renal vasodilation and renal blood flow 3. NSAIDs MOA -Blocks COX-1 and COX-2 which inhibits the formation of prostaglandins which interferes with the inflammatory response 4. COX-1 -Platelet aggregation -Blood flow to kidneys and stomach -Gastric acid secretion -Production of protective mucus in stomach - risk for AEs 5. COX-2 -Synthesized in response to pain and inflammation 6. NSAIDS exam- ples (traditional) -Ibuprofen -Naproxen -Indomethacin: very potent (not OTC) -Ketorolac: ONLY IM in drug class -Diclofenac: topical OTC 7. NSAIDS uses -Mild to moderate pain -Fever -Inflammation -EX: gout, tendonitis, menstrual cramping, RA -Not used as antiplatelet b/c antiplatelet activity is re- versed (only exist while in the blood only 6-8 hrs) 8. NSAIDs AEs -GI: N/V, dyspepsia, bleeding -Fluid retention and peripheral edema