NSC 330 feofibrate and gemfibrozil Fibric Acid Agents Questions With Complete Solution A+ 1. How does pravastatin differ from lovastatin - ANS-it is not metabolized via the P450 system and thus does not produce the drug interactions of lovastatin 2. How does fluvastatin differ from lovastatin - ANS-it is primarily metabolized via a different isoenzyme pathway 3. What is the purpose of fibric acid agents? - ANS-they can be used with statins to reduce triglycerides 4. What is feofibrate - ANS-a fibric acid agent used to reduce triglycerides 5. What is gemfibrizil - ANS-a fibric acid agent used to reduce triglycerides 6. What is the effect of feofibrate and gemfibrozil on LDL? - ANS-no effect, they are used to reduce triglycerides 7. What is the significance of rhabdomyolysis - ANS-it is an acute, sometimes fatal disease, in which direct injury to the plasma membrane of skeletal muscle occurs 8. What is the significance of checking CK levels - ANS-The CK level indicates muscle breakdown, when it is 10,000 U/L a diagnosis of rhabdomyolysis is made. 9. What are the consequences of rhabdomyolysis? - ANS-renal failure 10. What is the mechanism of action for feofibrate? - ANS-lowers plasma triglycerides by inhibiting