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Nsc 330 Lovastatin, Pravastatin, Fluvastatin Statins Qs&as 2023-2024
NSC 330 lovastatin, pravastatin, fluvastatin STATINS Qs&As 2023-2024
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NSC 330 lovastatin, pravastatin, fluvastatin STATINS Qs&As 2023-2024 What is the prototype drug for statins? - ANS-lovastatin (mevacor) ALT level - ANS-10 -40 U/L AST level - ANS-10 - 30 What is the therapeutic effect of lovastatin - ANS-primary hypercholesterolemia and hyperlipemia What is pharmacokineics of lovastatin - ANS-high first pass effect. Highly protein bound, excreted primarly through the GI What are the pharmacodynamics of lovastatin - ANS-it competitively inhibits HMG-Coa reductase, which is the enzyme that catalyzes the early rate-limiting step in cholesterol biosynthesis? How does malnutrition affect lovastatin? - ANS-More of the drug would be in the body What are the contraindications for lovastatin? - ANS-Liver disease and CATEGORY X for pregnancy What are the adverse effects for lovastatin - ANS-muscle and joint pain, weakness, cramps, rhabdomyolysis photosensitivity rhabdomyolysis - ANS-dissolution of striated muscle What are the drug interactions of lovastatin? - ANS-grapefreuit juice, itraconazole, erythromycinWhen should you administer lovastatin? - ANS-in the evening immediate release should be after a meal extended release should be at bedtime What test should be done prior to starting lovastatin? - ANS-liver function (alt and ast) What test should be done after starting lovastatin? - ANS-CK levels, liver function, muscle soreness What
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