NSC 330 Exam 1 Qs&As 1 / 54 1. Core Patient Vari- ables 2. Drug action is most pronounced in... 3. Effect of body weight on pharma- cology Age Body Weight Genetic and Ethnic Characteristics Gender Pathologic conditions pediatrics and geriatrics recommended dosage is targeted at the 150 lb per- son 4. Pharmacogenetics Genetically related variability in responses to drugs -may lack enzyme systems or overactive enzyme sys- tems -different metabolisms 5. Pharacognithropolo- gy 6. Gender variables and pharmacology 7. All pharmacokinetic processes are de- creased in a patient with... 8. Absorption of oral drugs are decreased with... 9. Distribution of drugs are altered in... racial and ethnic differences -for example, African Americans are less responsive to ACE inhibitors and beta blockers Males have more vascular muscles and effects are seen sooner. Females have more fat cells and drugs deposited in fat may be released slowly and cause effects for a prolonged period of time. CVD -this is characterized by decreased blood flow to tis- sues vomiting and diarrhea malnutrition, liver and valvular disease -effects of plasma proteinsNSC 330 Exam 1 Qs&As 2 / 54 10. Alterations in drug metabolism 11. Excretion of drugs is decreased in a pa- tient