NSC 330 Diuretic eplerenone Aldosterone blocker (eplerenone - diuretic) Questions And Answers A+ 1. How does eplerenone work? - ANS-It blocks aldosterone 2. What is the prototype drug for aldosterone inhibitors - ANS-eplerenone (Inspra) 3. What are the pharmacotherapeutics of eplerenone? - ANS-hypertension treatment 4. What are the pharmacokinetics of administration of eplerenone? - ANS-oral 5. What are the pharmacokinetics of metabolism of eplerenone? - ANS-liver 6. What are the pharmacokinetics of excretion of eplerenone? - ANS-urine and stool 7. What is the peak onset of eplerenone? - ANS-1.5 hours 8. What are the pharmacodynamics of eplerenone? - ANS-binds selectively to the mineralocorticoid receptors, thereby blocking aldosterone from binding to these receptors 9. What is the electrolyte that must be monitored when using eplerenone? - ANS-potassium 10. When is eplerenone contraindicated? - ANS-K+ level of 5.5 or higher 11. What is the nursing diagnoses and outcome for pts using eplerenone? - ANS-deficient knowledge r/t avoiding potassium supplements and potassium based salt substitutes12. How do you maximise the therapeutic effects for eplerenone? - ANS-pt education prior to and during therapy 13. How do you minimize the adverse effects for eplerenone? - ANS-monitor pts. serum potassium level periodically 14. and monthly assessments