Carboplatin's elimination by the kidneys occurs in a reliable manner that makes AUC the optimal method for dosing the drug. Basically, AUC is a method of expressing the intended exposure to the drug over time. Verification of carboplatin doses can be daunting if institutional policies are not clear regarding which formula to use under what conditions. In the absence of clear institutional direction, documentation in the orders and plan of care must state the process used to determine the intended dose. {Ans: Why use AUC instead of BSA for carboplatin dosing?}Burning, stinging pain around the administration site, although it is important to note that some patients do not experience any pain with vesicant extravasation and may in fact experience a feeling of coolness at the site (Polovich et al., 2014). {Ans: Extravasation signs and symptoms can include}Although hypersensitivity and infusion reactions can occur at any time and potentially with any chemotherapy agent, there are certain agents that have a higher risk of causing a reaction. For some agents, the reaction is more likely to occur after they have received a few doses and have already been exposed to the same agent. On the other hand, there are agents