Type 2 hypersensitivity {Ans: E. Antibodies directed against fixed antigens on the plasma membrane of cells C.M. Varies depending on alloimmune or autoimmune}Pathophysiology and clinical implications of folate deficient anemia {Ans: Folic acid is required for RBC synthesis, when lacking, cell continues to grow- but not mature, will get large and be destroyed in the bone marrow Monitor nutritional status of patients, elderly are easily malnourished ETOH dependent may need supplementation}causes of thrombus {Ans: Triad of Virchow- injury to blood vessels, abnormality in blood flow, hypercoagulability some medications increase risks}give CM and an example of coagulopathy hemorrhage {Ans: CM- joint bleeding, tissue hematomas, large spontaneous central ecchymosis, delayed bleeding after surgery, trauma or injury DIC}Pathophysiology and clinical implications of pernicious anemia {Ans: A Vitamin B12 deficient leads to fewer RBCs- intrinsic factor is lacking- RBCs get big, but not mature Macrocytic Typical at age 60 as 10 years of B12 is stored in body}Leukopenia {Ans: Decrease in number of total WBC}