Biochemistry Usmle Step 1 Questions And Answers 100% Verified A+ Guaranteed

HNPCC (Lynch syndrome) {Ans: AD DNA mismatch repair defect → colorectal, endometrial, & other cancers}NF2 gene, chromosome, presentation {Ans: AD merlin on 22 → bilateral acoustic neuromas, juvenile cataracts, meningiomas, ependymomas}Tyrosine {Ans: }microtubules for retrograde & anterograde transport {Ans: dynein = retrograde kinesin = anterograde}weakness begins in pelvic girdle muscles and progresses superiorly {Ans: Duchenne MD}pyruvate metabolism branchpoints {Ans: 1. alanine (AA to liver) via ALT 2. OAA (gluconeo or TCA cycle) via pyruvate carboxylase 3. acetyl-CoA (TCA cycle) via PDH 4. lactate (anaerobic glycolysis) via LDH}