Rush Nsg 531: Advanced Pharmacology Exam 2 Questions N Answers 2024/2025

Doxazosin (Cardura) {Ans: Alpha 1 receptor prototypic antagonist; used to manage HTN}Non-competitive (irreversible) antagonist LDR curve {Ans: Moves to the right and down}Cocaine {Ans: Binds to/blocks dopamine transporter increasing dopamine availability Non-selective: blocks reuptake of NE causing heightened sense of arousal and increased CV events}Neurotransmitter criteria {Ans: Must have the neurotransmitter (NT) already present in a presynaptic neuron terminal Must be Calcium dependent - presynaptic neuron depolarization opens up voltage-gated Ca+ ion channels and induces exocytotic release of the NT Must be specific receptors of the NT expressed on the cell membrane of the postsynaptic cell}Bethanechol {Ans: Muscarinic agonist prototype. Selective, binds to M3 receptors in the bladder and causes bladder muscle contraction and sphincter relaxation. Indicated for urinary retention in postop or pp pts. AEs: salivation, lacrimation, bronchospasm, diarrhea, and bradycardia}Ionotropic receptors {Ans: Ligand gated ion channels Ligand binds to receptor and opens up the channel and the ion can move across the membrane according to its concentration gradient Process mediates a very quick response}