Rush Nsg 531: Advanced Pharmacology Exam 2 -Questions & Correct Answers

Synthesis of NE {Ans: Occurs at adrenergic neuron; Tyrosine to DOPA to dopamine to NE. Binds to alpha and beta receptors. Degraded by COMT and MAO.}Non-competitive (irreversible) antagonist LDR curve {Ans: Moves to the right and down}SSRI {Ans: Reduced cAMP in brain of depressed ppl G protein trapped in lipid rafts and can't activate adenylyl cyclase Bind to G protein and move it closer to adenylyl cyclase Results in increased intraneuronal cAMP}Presynaptic GABA-B receptor {Ans: Inhibits the release of glutamate}Kd {Ans: Concentration of drug in the plasma when 50% of the target receptors are occupied. Mole/L}Ionotropic receptors {Ans: Ligand gated ion channels Ligand binds to receptor and opens up the channel and the ion can move across the membrane according to its concentration gradient Process mediates a very quick response}Albuterol {Ans: Beta 2 prototypic agonist; used to manage asthma}Flumazenil {Ans: GABA-A antagonist; reverse effects of benzo}Pilocarpine {Ans: Muscarinic agonist for glaucoma. Causes ciliary muscle contraction.}Phenylephrine {Ans: Alpha 1 receptor, prototypic agonist; used to induce mydriasis}PNS {Ans: Consists of long preganglionic fibers that originate from the medulla and the sacrum (sacral spine) to specific/singular/discrete short postganglionic fibers connecting to effector/target