Maryville Pharmacology Exam 1 Questions With Correct Answers

Type I hypersensitivity {Ans: A-allergic *IgE mediated- quick onset after exposure *production of IgE after antigen exposure. *urticaria, wheezing, rhinitis, anaphylaxis}Pharmacokinetcs {Ans: what the body does to the drug *absorption *distribution *biotransformation *elimination}What ADRs are the elderly at risk of developing? {Ans: -polypharmacy -Increased proportion of body fat (increased storage of fat soluble drugs) -increased cardiovascular effects -decreased metabolism in teh liver -decreased renal function -increased effect of drugs on the CNS}Administering 2 drugs that are metabolized by the p450 system requires: {Ans: When 2 drugs are both metabolized by the p450 system the drug should be administered at separate times to prevent the metabolism of one drug resulting in toxic effects of the other drug.}hypersensitivty reactions: mnemonic ACID {Ans: 1. A-allergic 2.C-cytotoxic 3.I- Immune complex deposition 4. D-delayed}CYPs (cytochrome P450) {Ans: *the major enzymes involved in drug metabolism accounting for about 75% of metabolism *most drugs undergo deactivation by the CYPs either directly or facilitated excretion from the body *many substances are bio activated by CYPs to form their active compounds}Which medications interact with St. John's Wort? {Ans: SSRI antidepressants, warfarin, and birth control. Combining St. John's Wort and SSRI antidepressants, could