Nurs 615 Pharm Exam 1 Maryville Questions With Verified Solutions (61 Questions) 2024 Update

What effect will result with rapid withdrawal of a beta blocker? {Ans: A coronary artery spasm that can result in an MI. This most often happens in a patient with a history of coronary artery disease.}Explain first pass metabolism. {Ans: This occurs when the concentration of the drug is greatly reduced before it reaches the systemic circulation. It is the portion of the drug lost during absorption. Generally, occurs in the liver or gut wall. After a drug is swallowed it is absorbed by the digestive system and enters the hepatic system. It is then carried by the portal vein to the liver before it reaches the rest of the body. The liver metabolizes many drugs to such an extent that only a small portion of the drug reaches the rest of the body. bioavailability of the drug thus is greatly reduced by the liver. Sublingual administration can bypass the first pass system plus it is also faster than oral route.}What effect is produced with cholinergic blockers? {Ans: An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in central and peripheral nervous system. Anticholinergics inhibit parasympathetic nerve impulses by selectively blocking the binding of neurotransmitter