Nurs 316 - Midterm - Athabasca University Study Guide Graded A+

Fenamates {Ans: Meclofenamate, Mefenamic Acid}Cancer Cell-Specific Agents {Ans: Imatinib (po) Erlotinib (po) Bortezemib (IV) ONLY effect cancer cells 1. Protein tyrosine kinase inhibitors - blocks enzyme needed for protein building 2. Epidermal growth factor - enzyme found in tumors 3. Proteasome inhibitor - proteasome causes tumour growth}Other Anti-inflammatories {Ans: Anakira Hyaluronidase Leflunomide Penacillamine Sodium Hyaluronate Tofactinib}Alkylating Agents {Ans: Chlorambucil (PO) -Kills in ALL phases of cell cycle -Reacts with DNA/RNA -Best for slow growing cancers Mostly IV Given in cycles Amifostine + Cisplatin Mesna + Ifosfomide Allopurinol}TNF Blockers {Ans: Etancercept (subcu) -TNF releases stuff that causes inflammation. Blocking this causes less inflammation -Serious fatal effects}Oxicam Dervitives {Ans: Meloxicam, Piroxicam}Anticoagulants {Ans: Heparin (subcu, IV) Warfarin - decreases vitamin k dependant clotting factors -INR -Vitamin K antidote Heparin - prevents prothrombin --> thrombin -Safest for pregnancy -Protamine Sulfate antidote}Salicylates {Ans: Aspirin (po) -Inhibits prostaglandin synthesis and TXA2 -Salicylism toxicity 20g for adults, 4g for children}Thrombolytic {Ans: Urokinase (IV) -Activates plasminogen to plasmin which breaks down fibrin and dissolves clot}Xarleto & Edoxaban {Ans: Blocks factor X}Mitotic Inhibitors {Ans: Vincristine (IV) -M phase -Excreted in feces -Can cause arrythmias}Antiplatelets {Ans: Aspirin (po)