Patietn Care- Ra (Rheumatology) Questions And Answers A+ 2024

Patietn Care- RA (Rheumatology) Questions And Answers A+ 2024 1 / 18 1. What is RA? Most common type of arthritis! (Surprising) An autoimmune or faulty immune system affects the wrist and small joints of the hand, including the knuckles and middle joints of the fingers. Results in systematic, erosive synovitis. 2. What are key vis- ible indicators of RA? 3. Epidemiology of RA Bone erosion, swollen/inflamed synovial membrane Usually presents in 5th decade, but may happen earlier (35-50) Increases prevalence in up to the eighth decade. MORE COMMON in FEMALES Leading cause of death in patients with RA is CARDIO- VASCULAR DISEASE. RISK OF DEATH INCREASED BY: Infections, malignan- cy, depression, and pulmonary disease 4. Juvenile RA RA with an onset at MHC CLass II --> CD4+ T Cells --> Cytokines/ B-Cell activations/ Endothelial activation --> PGE2, colla- genase ,stromelysin, elastase, released --> Pannus for- mation, destruction of bone, cartilage Enzymes involved in COMMUNICATION and signaling 7. What are JAKs? Janus associated kinases, prevalent in cell activation and proliferation in RA 8. Comorbidities in RA CVD- More than half of deaths with RA Infections- RA patients have increased risk of infection Malignancy- Increased risk of lymphoproliferative malig- nancies such