Discussion: Wk 1 Discussion Pharmacokinetics And Pharmacodynamics

Week 1 Discussion: Pharmacokinetics and PharmacodynamicsFor any drug to have a constructive or unconstructive effect internally, the medication must first go into the body and be absorbed into the bloodstream. During my career, I have come across several cases where pharmacodynamic and pharmacokinetic factors have altered a patient’s anticipated reaction to a drug. Most of the patients have been elderly. The variability in the rate of aging increases intersubject variability in reaction to xenobiotics compared with younger adults. A good illustration of decreased function in elderly people is impaired clearance operation in both the kidney and liver, resulting in a greater possibility of ADR from drug overdose (Rosenthal & Burchum, 2021). Notably, and from my experiences, illnesses of the kidney and liver are more common and normally more advanced in older persons than in younger age groups. Another factor that influences a patient’s anticipated reaction to a drug is the possibility for drug-drug or drug-environmental chemical interactions due to polypharmacy (Byrant & Knights, 2015). Polypharmacy which is the use of different drugs meant to address different conditions in a single patient can stress pharmacodynamic and pharmacokinetic systems that are already at a minimum level of operation caused by normal