COMPREHENSIVE EVIDENCE-BASED MANAGEMENT OF MODERATE TO SEVERE ACUTE ASTHMA EXACERBATION IN A YOUNG ADULT MALE: DIAGNOSTIC CHALLENGES, THERAPEUTIC STRATEGIES, AND PATIENT-CENTERED OUTCOMES Case IntroductionAaron Preston is a 29-year-old male with a known history of asthma who presents to the Emergency Department with acute onset of worsening shortness of breath, wheezing, and chest tightness. His symptoms began approximately 24 hours ago and have progressively worsened despite use of his rescue inhaler every 1-2 hours. He denies fever or chills but reports associated dry cough and chest discomfort. His past medical history is significant for childhood-onset asthma and seasonal allergic rhinitis. On arrival, he appears anxious and in moderate respiratory distress with tachypnea, tachycardia, and oxygen saturation below normal limits on room air. This presentation is consistent with an acute asthma exacerbation requiring prompt diagnostic evaluation and evidence-based management to prevent respiratory failure and optimize clinical outcomes. Patient Demographics Field Details Name Aaron Preston Age 29 years Sex Male Ethnicity Caucasian Height 510 (178 cm) Weight 185 lb (84 kg) BMI 26.5 kg/m Occupation Warehouse supervisor Insurance Employer-sponsored Location Emergency Department Reason for Encounter Acute asthma exacerbation Chief Complaint Im having trouble breathing and my inhaler isnt helping. History of Present Illness