Page 1 of 65 USMLE STEP 1 Pharmacology EXAM LATEST EXAM 2025 - 2026 SOLVED QUESTIONS & ANSWERS VERIFIED 100% GRADED A+ (LATEST VERSION) WELL REVISED AND HIGHLY RECOMMENDALE 100% GUARANTEE PASS USMLE STEP 1 Pharmacology What are the major functions of the 1 receptor? Increase vascular smooth muscle contraction, increase pupillary dilator muscle contraction (mydriasis), increase intestinal and bladder sphincter muscle contraction What are the major functions of the 2 receptor? Decrease sympathetic outflow, decrease insulin release, decrease lipolysis, increase platelet aggregation, decrease aqueous humor production What are the major functions of the 1 receptor? Increase heart rate, increase contractility, increase renin release, increase lipolysis What are the major functions of the 2 receptor? Vasodilation, bronchodilation, increase lipolysis, increase insulin release, decrease uterine tone (tocolysis), ciliary muscle relaxation, increase aqueous humor production What are the major functions of the M1 receptor? CNS, enteric nervous system What are the major functions of the M2 receptor? Decrease heart rate and contractility of atria What are the major functions of the M3 receptor? Increase exocrine gland secretions (e.g., lacrimal, salivary, gastric acid), increase gut peristalsis, increase bladder contraction, increase bronchoconstriction, pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accommodation) What are the