Page 1 of 102 USMLE STEP 1 Microbiology EXAM LATEST EXAM 2025 - 2026 SOLVED QUESTIONS & ANSWERS VERIFIED 100% GRADED A+ (LATEST VERSION) WELL REVISED AND HIGHLY RECOMMENDALE 100% GUARANTEE PASS What is a special cellular component of fungal membrane targeted in anti-fungal medication? Ergosterol A major sterol What is the special component of bacterial cell wall? Peptidoglycan Where are the normal flora found? Contributions to health? Causes of infection? Location: - found on body surfaces contiguous with outside environment (GI, etc.) - Semipermanent (dependent on life-changes) Contributions to health: - Protective functions by maintaining a certain pH other microorganisms cannot proliferate - Nutritional: synthesizing vitamin K + B Causes of infection: - "Getting lost" (E. coli to urethra causing UTI) - Overgrowth due to immunocompromised state Are there normal flora in the blood or organs? No Sterile environment What is a medically important normal flora found in the nose? Staphylococcus aureus What are the pathogenicity mechanisms? (8) 1. Colonization (adherence) 2. Avoiding immediate destruction by host defense sys. 3. "Hunting + Gathering" needed nutrients 4. Antigenic variation 5. Ability to survive intracellularly 6. Type III secretion systemsPage 2 of 102 7. Inflammation of Immune-mediated damage 8. Physical damage