Brs Pathology All Questions Study Guide Rated A+

The answer is C. The combination of membranous glomerulonephritis, pleuritis, and Libman-Sacks endocarditis (vegetations on both surfaces of the mitral or tricuspid valves) as well as proliferative splenic arteriolitis is characteristic of SLE. Diffuse interstitial pulmonary fibrosis also occurs in SLE. A variety of antinuclear antibodies (ANAs) are found; the most specific are antibodies to the Sm antigen, antibodies to double-stranded DNA, and antibodies that result in a peripheral rim pattern of nuclear immunofluorescence. {Ans: Membranous glomerulonephritis is found at autopsy in a 25-year-old woman who died in renal failure. Other autopsy findings include pleuritis, diffuse interstitial fibrosis of the lungs, concentric rings of collagen surrounding splenic arterioles, and warty vegetations of the mitral and tricuspid valves affecting the surfaces behind the cusps, as well as the surfaces exposed to the forward flow of blood. Which of the following is an expected laboratory finding? (A) Increased titer of antistreptolysin O (ASO) (B) Lymphocytosis (C) Peripheral rim pattern of antinuclear antibody fluorescence (D) Positive blood cultures for Streptococcus viridans (E) Serum antibodies reactive with glomerular and pulmonary alveolar basement membranes}The answer is B. Phospholipase A2 catalyzes the release of arachidonic acid from membrane phospholipids. Arachidonic acid metabolism then proceeds through