Nst 160 - Fatty Liver Disease Study Guide Graded A+

What is the leading cause of death in patients with NASH? {Ans: Cardiovascular disease}Lipid droplet formation {Ans: 1. On the membrane of the smooth ER, DGAT1 and DGAT2 increase TG synthesis 2. TG forms in the wall of smooth ER creating a lens 3. More TG is synthesized in the lens creating a lipid droplet}The occurrence of NAFLD is higher in patients with more components of? {Ans: metabolic syndrome}Risk factors for NAFLD/NASH {Ans: -Obesity -Diabetes -Hyperlipidemia -Hypertriglyceridemia -Hypertension -Metabolic syndrome}How does NAFLD lead to T2DM {Ans: causes increase in glucose production}How does NAFLD lead to atherogenesis {Ans: causes increase in glucose production, increase in cytokines, and increase in TG and ApoB}