Advanced Pharmacology-Nr 508 Study Guide Graded A+

Navajo Neuropathy {Ans: fatal autosomal recessive genetic disorder present in the Navajo population. Those with the illness display weakness, metabolic acidosis, neuropathy, and liver failure mutation on the MPV17 gene}adverse drug reaction {Ans: any unexpected, unintended, undesired, or excessive response to a medication given at therapeutic dosages (as opposed to overdose)}Risk factors for ADRs {Ans: genetic abnormalities age sex polypharmacy concomitant medical conditions}A primary care nurse practitioner (NP) prescribes a drug to an 80-year-old African-American woman. When selecting a drug and determining the correct dose, the NP should understand that the knowledge of how age, race, and gender may affect drug excretion is based on an understanding of: {Ans: pharmacokinetics.}beriberi or Wernicke's encephalopathy is associated with {Ans: Thiamine deficiency}A primary care NP has prescribed phentermine for a patient who is obese. The patient loses 10 lb in the first month but reports that the drug does not seem to be suppressing appetite as much as before. The NP should {Ans: discontinue the phentermine.}