Nr 565 Midterm Study Guide Questions And Correct Answers

Statement {Ans: The areas of healthcare that have most heavily integrated pharmacogenetics into clinical practice are those that work closely with disease states that are rooted in genetic abnormalities.}What would be the concern if a drug is a CYP450indicer? How that might affect the metabolism of another drug the patient is taking? {Ans: Cytochrome P450 enzymes are in cells throughout the body, primarily found in liver cells (Girvan & Munro, 2016). These enzymes are essential for the metabolism of many medications. Cytochrome P450 enzymes can act as an inducer or inhibitor of metabolism. When a medication induces the CYP450 enzyme that increases the rate of metabolism (Girvan & Munro, 2016). This can impact the effectiveness of other medications. For example, medication A induces CYP450 enzyme activity, therefore medication B will be metabolized quicker and have a less therapeutic effect.} {Ans: Epinephrine}What dosing of propranolol has been proven effective in reducing the incidence of migraine headaches? {Ans: Propranolol in doses of 20 to 80 mg 3 or 4 times daily has proved effective in reducing the incidence of migraine headache in some patients. The mechanism of action is related to prevention of beta receptor-induced vasodilation and promotion