Pharmacology 5334 Module 2 Study Guide Graded A+

The most important cause of adverse drug reactions in the elderly is {Ans: Drug accumulation secondary to reduced renal excretion}Foscarnet excretion {Ans: 10% to 20% of each dose is deposited in bone, the remainder is excreted in urine (reduce dose in renal impairment); half-life is 3-5 hours}Diarrhea causative organisms {Ans: Salmonella, shigella, campylobacter, E. Coli, c-diff, bacteroides fragilis}Intra-abdominal infection causative organisms {Ans: E. Coli, klebsiella, enterobacter, proteus}Isoniazid can cause serious adverse effects including: {Ans: Hepatitis, peripheral neuropathy, and seizures}Oral candidiasis treatment {Ans: Topical - nystatin, clotrimazole, miconazole, and ampho B; immunocompromised patients may need oral therapy with fluconazole or ketoconazole}