Nr 565 Midterm Study Guide Graded A+

What is the purpose of genetic testing for Tamoxifen? {Ans: CYP2D6 genetic testing for Tamoxifen is to reduce the risk of therapeutic failure. Recently, the ameliorative effects that variable isoforms of CYP2D6 have on the metabolism and therapeutic efficacy of tamoxifen in some patients have received much attention. With reference to tamoxifen, the role of CYP2D6 is not so much the metabolism of this drug as it is to activate it by conversion to endoxifen inside the cell. Pharmacogenetic variation in CYP2D6 has been shown in clinical trials conducted in the United Kingdom and Germany to lead to variable therapeutic outcomes to tamoxifen treatment of estrogen-sensitive cancers.}Key points: {Ans: BBs and clonidine are both drugs that require tapers when discontinuing} {Ans: Norepinephrine}What the terms efficacy and bioavailability mean? {Ans: According to Woo & Robinson (2016), efficacy in medicine means the power of producing the maximum effect of a drug (Woo & Robinson, 2016, p. 14). When thinking about efficacy and medication, an example may include hypertension medication and how it lowers blood pressure but can also have an effect on other mechanisms in the body such as heart rate or kidney function. Patients who are prescribed