Nr 565 Midterm Study Guide Graded A+

Why do BBs, and clonidine require tapers when discontinuing them? {Ans: Abruptly stopping certain medications such as beta-blockers and clonidine without gradually tapering down the dosages can lead to withdrawal syndromes. Discontinuing cardiovascular drugs like propranolol and clonidine can result in rebound hypertension and increases the risk of cardiovascular events. If a patient taking clonidine suddenly stops taking it, his or her blood pressure will spike dangerous and can even cause a stroke (Akram et al., 2020). Other withdrawal symptoms from clonidine can include nervousness, headache, and tremors (Akram et al., 2020). Similarly, suddenly stopping propranolol or other beta-blockers can cause a spike in blood pressure as well as tachycardia that can even lead to chest pain and potentially a heart attack (Akron et al., 2020).}What are some differences in drug metabolism in Asian populations? {Ans: One of the biggest differences in drug metabolism derives from the fact that Asian populations typically have reduced activity of the CYP450 2D6 and 2C19 enzymes (Woo & Robinson, 2016). Specifically, the 2D6 isoenzyme is responsible for metabolism of antiarrhythmics, antidepressants, and neuroleptics so the metabolism of these drugs are slower than other racial groups (Woo & Robinson, 2016). Given that, the