Evidence-Based Medicine {Ans: - The conscientious, explicit, judicious and reasonable use of modern, best evidence in making decisions about the care of individual patients.}Specificity {Ans: - Specificity refers to the ability of testing to recognize patients who do not have the disease. - For example, D-Dimer has high sensitivity and will be positive in most cases of PE; however, this comes at the cost of a high false positive rate due to low specificity. A confirmatory, more specific, imaging test may be required to make the diagnosis.}Nodule {Ans: - Description: Larger papule, solid - Potential Cause: Erythema nodoscum, fungal or atypical mycobacterial infections}Specificity Formula {Ans: - To calculate specificity, the number of patients who test negative and do not have the disease (true negative = TN) is divided by the total number without the disease, including those who falsely test positive (false positive = FP). - TN/(TN + FP)}Positive Predictive Value (PPV) {Ans: - Positive Predictive Value (PPV) reports the probability that a patient has the disease after testing positive for it. Positive predictive value is markedly dependent on the prevalence of the disease in question. - TP/(TP + FP)}Rosacea {Ans: - Rosacea is