Pharmacology Test #1: Lehne Study Guide Rated A+

transcription factors {Ans: found within the cell & responses to activation are delayed--are situated on DNA in cell nucleus, regulate protein synthesis}G protein-coupled receptor systems {Ans: An endogenous ligand or agonist drug activates receptor => activates G protein => activates effector. i.e. serotonin, histamine}protein bound drugs {Ans: Affects the distribution of a drug; when the drug is bound to protein, it is unable to pass through capillary walls; may cause drug toxicity. when the patient has a lower-than-expected protein level, the distribution of the drug is altered.}cell membrane embedded enzymes {Ans: Receptors that span the cell membrane; domain is located on the cell surface with the enzyme's catalytic site inside; response occurs in seconds. i.e. insulin}Iatrogenic ADR {Ans: Physician induced}black box warning {Ans: a warning statement required by the FDA indicating a serious or even life-threatening adverse reaction from a drug; the warning statement is on the product package insert (PPI) for the pharmacy staff and in the MedGuide for consumers}allergic reaction {Ans: a sensitivity of the immune system independent of dosage size --anaphylaxis --PCN and aspirin often cause allergic reactions}awareness of complimentary/alternative drug therapies {Ans: ...}"affinity" {Ans: attraction between drug