Fundamentals Of Chemotherapy Immunotherapy Administration Exam 2023

Imatinib {Ans: -TKI -leukemia -ORAL ONLY -monitor GI upset, and weight gain}Prostate cancer (hormone therapy) {Ans: -androgen (testosterone) cause prostate cell growth -androgen suppression decreases testosterone -castration resistant (less effective over time)}Nitrosoureas {Ans: can cross the blood-brain barrier -inhibit DNA/RNA synthesis -interfere with enzymes to copy/repair DNA -long nadir (4-6 weeks)}Flare reaction {Ans: localized allergic reaction along a vein caused by irritating drugs}Antiangiogenic Agents {Ans: -keep new blood vessels from forming -prevent growth of new blood vessels tumors need to grow}Partial response {Ans: Measurable tumor reduced by 50% for at least one month with no new tumors}Cytokines {Ans: -proteins made by immune and non-immune cells -can be made in lab -some stimulate immune system, some slow it down}Camptothecins {Ans: -topoisomerase I inhibitor -drug blocks enzyme that helps unwind strands in cell reproduction}Leucovorin calcium {Ans: -chemoprotective and chemosensitizing agent -form of folic acid -drug used to lessen toxic effects of methotrexate which blocks action of folic acid.}Hodgkin lymphoma {Ans: Reed-Sternberg cell (cancer cells in classic) -typically starts in B cells}Immune-related adverse events (irAEs) {Ans: -inflammation in one or more organ systems -Grade 1 = continue therapy -Grade 2 = hold