Advanced Pathophysiology Exam #2

S/S [Clinical Manifestations] of Splenic Disease {Ans: 1. Infections: May cause fragile splenomegaly with possible rupture 2. Congestive: Ascites, portal HTN, esophageal varices 3. Malignancies of the Spleen: - Polycythemia rubra vera - Thrombocytopenia - Chronic leukemia - Hodgkin disease - Acute leukemia - Metastatic solid tumor [rare)}Lymphoma [Hodgkins] {Ans: - Proliferation of lymphocytes and histocytes - 3 Categories based on cell morphology/origin a) B cell b) T cell -Non-Hodgkin's lymphoma) c) Hodgkin's disease - 5th most common cause of death from CA - Etiology: UNK}Kawasaki vs Streptococcal Scarlet Fever - Palms and Soles {Ans: - Kawasaki: - Painful erythema, edema of palms and soles - Scarlet Fever: * Palms and soles are typically SPARED}Hand, Foot and Mouth disease - TX: - Symptomatic, rash heals 7 days w/o scarring {Ans: - Contagious enteroviral infection - Etiology: a) coxsackievirus A16 b) enterovirus 71 - Spread by oral/fecal and respiratory droplets - Exanthem - Vesicular palmoplantar eruption - Erosive stomatitis [aphtous-like) - In mouth - Palms, feet and posterior pharynx affected}Types of Leukocytes: - Granular {Ans: - Categorized according to the presence or absence of granules in the cell cytoplasm - *Granular Leukocytes*: - PMNs - Polymorphonuclear