Week 8 Nr 546 Exam Questions (33 Terms) With Verified Definitions Updated 2024

Prescribing Pearls Memantine (Namenda) {Ans: Prescribing Pearls This is used as monotherapy or in conjunction with ChEIs; when given with ChEIs, fall precautions are required and driving is forbidden due to delayed reactions. Minimal inhibition of CYP450 enzymes CYP1A2, CYP2A6, CYP2C9, CYP2D6, CYP2E1, and CYP3A4 occurs, which means there are no pharmacokinetic interactions with medications metabolized by these enzymes}N-methyl-D-aspartate (NMDA) Receptor Antagonist Prescribing Pearls {Ans: Prescribing Pearls Memantine is associated with an increased life expectancy when compared to donepezil (Procyshyn et al., 2018). If treatment failure occurs, 50% of individuals respond to a different agent (Procyshyn et al., 2018). Educate clients and families that medications cannot halt or reverse the progression of Alzheimer's disease. Consider goals of care in the selection of medication. Is the management of a specific symptom or behavior the goal? Is the associated risk of the medication worth the potential benefit? These goals will inform the selection of an agent. Donepezil at a higher dose has a higher incidence of adverse effects without increased cognitive benefit. Rivastigmine (Exelon) is available in oral form or transdermal patch. The transdermal patch is used for dementia associated with Parkinson's disease. Medications that induce or inhibit CYP450 metabolism