Nr566 Final (Advanced Pharmacology For Care Of The Family) Study Guide Graded A+

Anti-Androgens {Ans: } Finasteride (Propecia) Leuprolide (Eligard, Lupron, Lupron Depot) Spironolactone (Aldactone)Finasteride (Propecia, Proscar) {Ans: } blocks conversion of testosterone to dihydrotesterone Used to tx: -BPH -male pattern baldness 3 months of therapy need to see benefits Stopping, reverses effect w/in 12 months Adverse side effects: - Decreased libido -Impotencedutasteride (Avodart) {Ans: } 5-alpha reductase inhibitor used to tx: BPH Can stay in serum up to 6 mon after discontinuing can be absorbed through skin pregnant woman shouldn't handle capsules (fetal anomaly in male fetus) Adverse Effects decreased libido ImpotenceLeuprolide Acetate (Lupron) {Ans: } Luteinizing hormone - releasing agonist create reversible: -orchiectomy state -oophorectomy state Used to tx: - advanced prostatic cancer - Management of endometriosis - Uterine fibroids - polycystic ovarian disease - central precocious puberty in pedsFlutamide (Eulexin, Euflex) {Ans: } Truly non-steroidal agent Used to tx: -Advanced prostate cancer -female androgen excess syndrome Adverse Effects in males - gynecomastia -reversible liver toxicity Black Box Warning -hepatic failure -hepatic encephalopathy Basline/monthly liver function test for 1st 4 monthsSpironolactone (Aldactone) {Ans: } aldosterone antagonist potassium sparing diuretic used for tx: -female hirsutism (abnormal growth of hair) -acne -relief of PMS/PMDD symptoms (25-50 mg/d) Adverse reactions - dose related +