Thiothixene {Ans: Typical FGA (conventional) -dopamine 2 antagonist -High potency Indication: Schizophrenia, bipolar disorder, other psychotic disorders. -Dosing: 15-30 mg/day, initial 5-10 (max 60mg/day) Risk: Neuroleptic-induced deficit syndrome Akathisia Parkinsonism Tardive dyskinesia Sedation Dry mouth, constipation, vision disturbance hypotension}Amygdala and fear {Ans: affect or feeling of fear may be regulated via the reciprocal connections the amygdala shares with key areas of prefrontal cortex that regulate emotions, namely the orbitofrontal cortex and the anterior cingulate cortex}Histamine Receptor Antagonists: clinical pearls {Ans: -It is unclear if efficacy is due to an anxiolytic effect or a sedative effect. -Caution clients about potential sedation when prescribing. -When used concurrently with another central nervous system (CNS) depressant, the depressant dose should be reduced to half. -Elderly clients are more sensitive to the sedative and anticholinergic side effects of hydroxyzine.}SSRI's: clinical pearls {Ans: -Dosage should be started at half the recommended dose for depression, increase dosage after 2-4 weeks as needed to control anxiety. -SSRIs should not be stopped abruptly because it can result in rebound anxiety.}Nicotine is an inducer of the CYP 1A2 enzyme. Does the PMHNP anticipate Joshua may need a higher or lower dose of olanzapine to achieve a