NUR 615 PHARM EXAM 3PHARM EXAM 3 GOUT Lab Values o RFP, BUN, CR Colchicine. Low dose is 1.2mg followed by 0.6mg one hour later or 1.8 milligrams total :igh dose is 1.2mg followed by 0.6mg every four to six hours; or 4.8mg total. Low dose is as effective as high dose with lower side effects Side Effects o Always causes severe diarrhea Febuxostat (Uloric) =nitially gout may worsen Corticosteroids Side effects when administered 6+ months o Osteoporosis o Can worsen diabetes control o Patients should report any black tarry stools and abdominal pain Why Taper? o Tapering must be done carefully to avoid both recurrent activity of the underlying disease process and possible cortisol deficiency resulting from the hypothalamic - pituitary - adrenal axis or :PA suppression during the period of steroid therapy NSA=DS =ncrease risk of serious cardiovascular thrombotic events (M= and Stroke) may be fatal: May increase with duration of use. Patients with prior heart issues are more at risk. Serious G= effects (bleeding, ulceration, perforation) Elderly at more risk Can occur at any time with no warning For Pain start with NSA=DS and work your way up with medications =buprofen =nhibiting the cox enzymes cox which