Cleft Lip And Cleft Palate Powerpoint Presentation

Cleft Lip and Cleft PalateNameProfessorCourseDate Overview Causes Chromosomal AbnormalitiesThe main suspected chromosomal abnormality believed to be responsible for cleft lip and palate is “a particular type of chromosome rearrangement in which parts of two chromosomes switch places” (NIH 1).The chromosomal rearrangement causes the SUMO1 gene to split.The image to the right shows a SUMOI gene (center) that has been split during chromosomal rearrangement (top left). (NIH 1). However, the observation is only a correlative study. This is not the sole cause, as a split SUMOI gene does not always result in a cleft lip or palate.Expression of the MAFB gene has also been linked to palate formation. A lack of expression of the MAFB gene can also result in a cleft lip or palate (Kuska 1).Image source: NIH 1. Normal vs. Abnormal SituationA normal lip is fused in the center, often with a slight ridge where the fusion occurs. A normal palate is also fused down the center of the roof of the mouth.In both cleft lip and cleft palate, clefts appear as pictured. Note that a cleft palate is not visible when the mouth is closed. This can be more difficult to detect and may not be observed immediately