Review Notes For Advanced Patho Exam 3 Summer 2019

1 | P a g e Review Notes for Advanced Patho Exam 3 Summer 2019Hematological AlterationsKnow lab values for a person with anemia* What hemoglobin is concerning or indicates anemia? Less than 12 for men and less than 15 for women.Erythrocytes (red blood cells [RBCs]) An RBC is a small disk with two unique properties: (1) a biconcave shape and(2) the capacity to be reversibly deformed . Responsible for oxygenation-the shape allows for optimal gas exchange Average lifespan of an erythrocyte- 120 daysHemoglobin synthesis : very dependent on nutritional intake. IRON (Male: 16g/dl; female: 14g/dl) Two most important nutrients for hemoglobin synthesis- Iron and B6Iron Cycle recycled made possible by the plasma carrier, transferrin. Tissue macrophages (primarily in the spleen) break down ingested erythrocytes and return iron to the bloodstream directly or after storing it. The spleen removes mature erythrocytes from the bloodstream; spleen is where iron is broken down How do we store it (2 ways)- f erritin and hemosiderin What is used to recycle iron- transferrinLeukocytes (white blood cells [WBCs ]) defend the body against microorganisms that cause infection and remove debris, including dead or injured cells of all kinds. Act primarily in the tissues but are transported