REPLIES ISIOMA NWAEMEThe unresponsiveness of the patient is indicative of opiate overdose. The evidence for the opiate overdose is the action of Naloxone, a peripherally acting opioid antagonist capable of passing the blood-brain barrier. I think that the Necrosis occurred due to decreased blood flow to the vessels that supply blood to the forearm and trochanter. Some of the effects of opiate overdose are depressed breathing hypotension and rhabdomyolysis. The hyperkaliaemic state and abnormal electrolytes may be due to disruption of the ATP cycle, and hypoxia leading to cellular damage.Genetics has a significant role in drug addiction although stress and exposure have significant influence. Exposure to stressful conditions in early childhood may predispose individuals to substance abuse in adulthood. The way people react to stress and addiction are results of both genetic and environmental influences.ReferencesBuchanan, T. W., & Lovallo, W. R. (2019). The role of genetics in stress effects on health and addiction. Current Opinion in Psychology, 27, 72-76. https://doi.org/10.1016/j.copsyc.2018.09.005Dawn HallThe case study reveals a case of opioid overdose due to excessive opiate stimulation. The patient responded to the administration of Naloxone, an opioid antagonist. This means that the cause of the patient’s unresponsiveness was drug-induced. The opioid overdose