psychosis neurobiological factors: Neural signaling {Ans: Dopamine Role in Psychosis -leading hypothesis is that psychosis and schizophrenia are associated with a dysfunction of the neurotransmitter dopamine (DA) • Traditionally, schizophrenia and psychosis symptoms have been associated with a surplus of dopamine, since medications that block dopamine, specifically D2, have been found to reduce the positive symptoms of schizophrenia -schizophrenia symptoms are related to "out of tune" dopamine -Dopamine dysfunctions are also involved in other conditions that cause psychosis, such as severe depression, certain medical disorders, and substance abuse}treatment of psychotic disorders {Ans: complex -Decision-making about medications is influenced by treatment response and side effects, as well as the phase of illness (acute vs. stable) -antipsychotics as well as other medications, psychotherapy, and close collaboration between providers and the client's support system -Treatment goal setting should be client-driven, though some clients may be too ill or agitated to participate in the process -care should include the client's wishes, safety is of paramount importance • Providers may need to initiate treatment and/or hospitalization against a client's will}Orexin Receptor Antagonists {Ans: Orexin is a neurotransmitter that assists with alertness and wakefulness -Dual orexin receptor antagonists (DORA) promote sleep by blocking