Nr566 Midterm Week 4 Advanced Pharmacology Study Notes & Key Concepts | 2025 Edition | A+ Guaranteed | 100% Pass

NR566 Midterm Week 4 - Advanced Pharmacology Study Notes & Key Concepts 2025 Edition A+ Guaranteed 100% Pass Week 1 What factors would you consider when selecting a protease inhibitor for a patient with HIV who has experienced treatment failure with other antiretroviral drugs? - PIs are active against both HIV 1 and HIV 2. - When used in combination with NRTIs, they can reduce viral load to a level that is undetectable with current assays - As with other antiretroviral drugs, HIV resistance can be a significant problem. - Mutant strains of HIV that are resistant to one PI are likely to be cross-resistant to other PIs. - To reduce the risk for resistance, PI should never be used alone; rather they should always be combined with at least one reverse transcriptase inhibitors and preferably two. How would you adjust the antifungal therapy for an older adult patient with a fungal infection and a history of altered gastric pH? - Drugs like antacids, Histamine-2 antagonists and PPI can greatly reduce absorption of itraconazole. - These agents should be administered at least one hour before itraconazole or two hours after. - Because PPI have prolonged duration of action, patient using