Nr 565 Advanced Pharmacology Midterm Exam | Chamberlain University | 2025 Verified Questions & Answers | A+ Study Guide

NR 565 Advanced Pharmacology Midterm Exam Chamberlain University 2025 Verified Questions & Answers A+ Study Guide During what trimester is a pregnant woman most at risk for adverse drug reactions with potential long term consequences? 1st trimester (fetus most at risk d/t rapid growth) >What is BEERS criteria? Recommendations of medications inappropriate for elderly (65 and older), prescriber ultimately decides >What is the CYP450 (cytochrome P450) liver enzyme system where medications are metabolized, can either be inducers or inhibitors and create drug-drug interactions >CYP450 inducers Speed up metabolism of drugs (drug is cleared faster), drug has lesser effect (decrease blood levels of drug), elevate CYP450 enzymes >CYP450 inducers pneumonic "Bullshit Crap GPS INDUCES rage" >CYP450 inducer drug names Barbituates, St John wort, Carbamazepine, rifampin, alcohol, phenytoin, griseofulvin, phenobarbital, sulfonylureas >CYP450 inhibitors inhibit metabolism, increase blood levels of medications >CYP450 pneumonic "VISA credit card debt INHIBITS spending on designers like CK to look GQ" >CYP450 inhibitors drug names Valproate, isoniazid, sulfonamides, amiodarone, chloramphenicol, ketoconazole, grapefruit juice, quinidine >Physiological changes during pregnancy that impact pharmacodynamics and pharmacokinetic properties of drugs? increase glomerular filtration rate leads to increase durg excretion increase hepatic metabolism decrease tone and motility of bowel increase drug absorption >Examples