Anesthesia Week 9 EXAM 2025 QUESTIONS AND CORRECT ANSWER What is the only local anesthetic that causes vasoconstriction? cocaine DEA schedule II for nasal surgeries Local anesthetics have a _________________ aromatic group and a _____________ amine group with an intermediate chain. lipophilic, hydrophilic amide (NHC) hepatic metabolism ester (CO) plasma esterase metabolism What is the mechanism of action of local anesthetics? block voltage gated Na channels intracellular access binding site impedes membrane depolarization cannot form action potential What are the two forms of local anestehtics? non-ionized (neutral base) easily cross the cell membrane, expansion and closure of Na channel ionized (charged) water soluble, can cross the open channel but don't cross the cell membrane, interact with the receptor in the intracellular site What is the differential blockage of local anesthetics? vasodilation sensory motor return of blockage is the same (except brachial plexus) B > C / A-delta > A-gamma > A-beta > A-alpha (drink good beer always ) 1 = B autonomic2 = C autonomic, slow pain, temp 2 = A-delta fast pain, touch, temp 3 = A-gamma muscle tone 4 = A-beta motor & sensory (touch, pressure) 5 = A-alpha motor and proprioception What is the onset of local