NAPLEX EXAM 2024-2024 UPDATED EXAM QUESTIONS AND ACCURATE ANSWERS VERIFIED 100% Identify the Therapeutic Drug Levels Carbamazepine: 4-12 Digoxin: 0.8-2 (AFib), 0.5-0.9 (HF) Gentamicin/Tobramycin: 5-10 (peak), 190 High-Intensity Statin Primary Prevention with Diabetes, age 40-75 and LDL between 70-189 MULTIPLE ASCVD RF High-Intensity Statin REGARDLESS OF ASCVD RISK Mod-Intensity Primary Prevention with age 40-75 and LDL between 70-189 ASCVD RISK >20% High-Intensity Statin ASCVD RISK 7.5-19.9% Mod-Intensity StatinStatin Equivalent Doses Pharmacists Rock At Saving Lives & Preventing Fatty-deposits Pitava - 2 mg Rosuva - 5 mg Aorva - 10 mg Simva - 20 mg Lova - 40 mg Prava - 40 mg Fluva - 80 mg Reduce the Risk of Statin Myalgias Avoid Drug interactions, including OTCs. Do not use Simvastatin 80 mg/day Do not use Gemfibrozil + Statin Managing Statin Myalgias Hold statin, check CPK. investigate other possible causes. After 2-4 weeks, re-challenge same statin or decrease dose. Most patients who did not tolerate at first will tolerate it when re-challenged, or will tolerate a different statin. If myalgias return, D/C statin. Once myalgia resolves, use low dose of different statin; gradually increase dose. Strong CYP3A4 Inhibitors to Avoid with Simvastatin and Lovastatin Itra, Keto, Posa, Voriconazole Erythro, Clarithromycin