ACTUAL EXAM PMHNP Study Set for ANCC PMHNP SET FOR ANCC COMPREHENSIVE TEST BANK FINAL EXAM 2024-2025 LATEST VOLUME WITH UPDATED QUESTIONS AND ACCURATE SOLUTIONS VERIFIED 100% ALREADY GRADED A+ 1. Review the MOA/DOSAGE for pharmacological therapy for a patient on stimulant medication(s) for ADHD. (p. 747) **Note: medication therapy, not first-line **Beware of stimulant use for children with tics **Rx'ing stimulants: ALWAYS assess cardiac risk because can lead to sudden cardiac death a. MOA: inhibit reuptake of dopamine and norepinephrine, thereby increasing concentrations in the presynaptic cleft. Amphetamines directly stimulate the release of dopamine and norepinephrine. b. DOSAGE: Start low, titrate up. =n adults, they were extended-release preferred to maximize compliance and minimize the risk of abuse. =n children, start with short-acting to gauge tolerability and response, then switch to a longer acting. Clozapine Chemical Structure SDA - Serotonin 5:T2A Dopamine D2 antagonist. Clozapine S/E 1. NO EPS, NO TD, NO :yperprolactinemia 2. Life-threatening S/E agranulocytosis 3. highest risk for MetX/Cardio-Metabolic, the greatest degree of weight gain4. =ncreased risk of seizures 5. Sedating, hypersalivation, risk of myocarditis Clozapine Tx Benefits 1. Reduce the risk of suicide in Schizo 2. Efficacy in treating aggression and violence 3. Reduce TD severity