Drug interaction {Ans: increased or decreased effect of one drug on another}Substantia Nigra {Ans: An area of the midbrain that is involved in motor control and contains a large concentration of dopamine-producing neurons part of basal ganglia}Parkinson's disease {Ans: chronic, progressive, neurodegenerative disorder affect dopamine producing neurons in brain cause: imbalance of two neurotransmitters; dopamine and acetylcholine}Older Adult Considerations: Excretion {Ans: Decreased glomerular filtration rate Decreased number of intact nephrons}Dopamine replacement {Ans: presynaptic levodopa- increased levels needed= adverse effects carbidopa given with b/c less levodopa needed, can't cross bbb alone adverse effects: dizziness, synope}type 1 diabetes mellitus {Ans: sudden onset , auto immune response, diabetes caused by a total lack of insulin production or defective insulin made; usually develops in childhood, and patients require exogenous insulin replacement therapy to control the disorder, fewer: 10% Complications: DKA(diabetic ketoacidosis)- keytone bodies in urine, HHS (hyperosmolar hyperglycemic state)}