Lehne's Pharmacology Test 1 Exam Questions (98 Terms) With Verified Definitions Updated 2024

Pharmacokinetics {Ans: The affect the body has on drugs. The movement of drugs through the body.}Clinical Testing Phase I {Ans: 2-10 years. Phase I: conducted in healthy volunteers or in volunteer patients who have the disease. Evaluates drug metabolism, pharmacokinetics, and biologic effects.}pH partitioning (ion trapping) {Ans: Drug molecules tend to accumulate on the side of the membrane where the pH most favors their ionization. Acidic drugs will accumulate on the alkaline side and basic drugs will accumulate on the acidic side.}Antagonists: {Ans: Produce their effects by preventing receptor activation by endogenous regulatory molecules and drugs. It has affinity but no intrinsic activity. They can block the actions of endogenous regulatory molecules or drugs.}Transcription Factors: {Ans: Are found within the cell rather than on it. Responses to activation of these receptors are delayed. Activation by agonist drugs initiates transcription of messenger RNA, which act as templates for synthesis of specific proteins.}First Pass Effect: {Ans: The rapid hepatic inactivation of certain oral drugs. If the capacity of the liver to metabolize a drug is extremely high, that drug can be completely inactivated on its first pass through the liver and no therapeutic effects can occur.}