Toxicology Exam 1 New Full Exam Questions And Answers ( Included ) 100% Correct

Complete Carcinogen {Ans: Chemical is an initiator and a promotor.}When should multiple dose charcoal be administered? {Ans: For toxins that undergo enterohepatic recirculation.}Teratology {Ans: Refers to study of congenital malformations}How is vitamin K used as an antidote? {Ans: Given at the right dose can provide enough vitamin K for coagulant factors. Rodenticides will block vitamin K epoxide reductase which is important for synthesis of vit K.}Be able to describe acetaminophen toxicity and mechanism of toxicity {Ans: Acetaminophen is usually conjugated and excreted. A very small percent is metabolized by p450 in the liver and later metabolized by GSH for excretion. When you have an overdose situation, the intermediate metabolite builds up (less is conjugated) and GSH is used up, thus toxic metabolite (benzoquinolomine) binds to macromolecules and causes toxic effect. Reactive intermediate especially problem in cats and causes oxidation of Hb.}How much active toxicant reaches the target depends on ? {Ans: Absorption, distribution, metabolism and excretion}