Phm 450 Exam 2 Prep Questions & Answers 2024

lead {Ans: Children are most vulnerable to lead exposure Animal studies show that lead exposure results in peripheral neuropathy with prominent segmental demyelination Adult humans - peripheral neuropathy}hepatocyte function {Ans: In summary, the important functions of hepatocytes include: Nutrient extraction from the bloodstream Protein metabolism Lipid and cholesterol metabolism Bile formation and secretion Glucose synthesis and glycogen storage Metabolism and detoxification of foreign compounds Oval cells are more likely to replicate following chemical injury, while hepatocyte proliferation is more likely to follow surgical removal of tissue.}Biotransformation and metabolism {Ans: The terms biotransformation and metabolism are often used interchangeably. Biotransformation refers to the chemical change of a compound within a biological system, while metabolism refers to the process by which biotransformation takes place}The irreversible lesions that are characteristic of cirrhosis result from deposition of __________ by fibroblasts. A) Epithelial cells B) Lipids C) Bile acids D) Collagen {Ans: d}Acinar Zones {Ans: Zone 1 is the periportal region immediately surrounding the portal tract. Cells in this region receive first contact with sinusoidal blood that is rich in oxygen and nutrients, as well as first contact with compounds that will undergo hepatic metabolism. Hepatocytes in Zone 1 contain