Cmpp Heart Failure (Test 1) Study Guide Rated A+

ARNI side effects {Ans: 1. renal dysfunction 2. hypotension 3. hyperkalemia 4. angioedema (*very rare, more common in Black people*)}heart failure with mildly reduced ejection fraction (HFmrEF) {Ans: LVEF 41-49% and/or evidence of increased LV filling pressures *seen on echo*}heart failure with reduced ejection fraction (HFrEF) {Ans: -LVEF < 40% -"systolic dysfunction"}spironolactone contraindications {Ans: 1. hyperkalemia 2. renal failure/anuria 3. addison disease 4. hypersensitivity/anaphylaxis}Angiotensin Receptor Neprilysin Inhibitor (ARNI) {Ans: -sacubitril/valsartan (entresto) -*very expensive* -valsartan: reduces afterload through vasodilation -sacubitril/neprilysin inhibitor: increases excretion of sodium/increased urine output -> reduces volume (*hits different part of kidney*)}ARNI contraindications {Ans: 1. angioedema 2. pregnant/breastfeeding 3. currently on ACEI/ARBs 4. hypersensitivity/anaphylaxis 5. currently taking aliskiren (tekturna): renin inhibitor}